Our objectives in this investigation are: 1. The standardization of the Thermokeratoplasty procedure by combining the retrospective study with a true prospective study. 2. The role of the Thermokeratoplasty procedure in the treatment of keratoconus will be determined and compared with more conventional procedures such as penetrating keratoplasty and lamellar keratoplasty. 3. The effect of Thermokeratoplasty on the corneal endothelium will be evaluated by pachometry, specular biomicroscopy and histopathology. 4. The effect of the Thermokeratoplasty on the correction of corneal astigmatism will be evaluated. 5. We will continue our ongoing studies on other modalities of treatment for keratoconus. 6. We will continue our present studies on pharmacogenetics and genetics of keratoconus.